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Cargo quantification of functionalized DNA origami for therapeutic application
Olivia J Young1,2,3,4, Hawa Dembele1,2,3,5, Anjali Rajwar1,2,3
1Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Biorxiv : the Preprint Server for Biology
|September 10, 2024
Summary
Researchers have developed methods to quantify cargo on DNA origami nanoparticles, crucial for advancing nanotechnology-based drug delivery and therapeutic applications.
Area of Science:
- Nanotechnology
- Biotechnology
- Molecular Biology
Background:
- DNA origami nanoparticles offer precise control over nanoscale cargo placement.
- These nanoparticles have diverse applications in diagnostics and therapeutics.
- Quantifying cargo on these nanoparticles is essential for their development.
Purpose of the Study:
- To consolidate and present validated methods for quantifying cargo on DNA origami nanoparticles.
- To provide a resource for researchers utilizing these nanoparticles in therapeutic applications.
Main Methods:
- Focus on gel-based and fluorescence-based quantification techniques.
- Includes multiplexed quantification of protein, peptide, and nucleic acid cargo.
Main Results:
- Demonstrated effective quantification of various cargo types on DNA origami nanoparticles.
- Validated methods suitable for diverse research and therapeutic applications.
Conclusions:
- Established reliable methods for cargo quantification on DNA origami nanoparticles.
- This work supports the advancement of DNA origami-based nanotherapeutics.
