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Updated: Jun 13, 2025

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Posterior Eye Shape in Myopia.

Jost B Jonas1,2,3,4,5, Songhomitra Panda-Jonas1,3,6, Zhe Pan7

  • 1Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France.

Ophthalmology Science
|September 10, 2024
PubMed
Summary
This summary is machine-generated.

Longer axial length is associated with an extrafoveal location of the posterior eye's retinal pigment epithelium/Bruch's membrane line. This finding may impact biometric measurements and suggests asymmetric enlargement of Bruch's membrane.

Keywords:
Axial elongationBeijing Eye StudyDome-shaped maculaHigh myopiaMacular ridges

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Ocular Biometry

Background:

  • Posterior eye shape abnormalities can influence visual function and biometric measurements.
  • Understanding the factors associated with these abnormalities is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To investigate the prevalence and associated factors of posterior eye shape abnormalities, specifically the location of the posterior point of the retinal pigment epithelium/Bruch's membrane line (PP-RPE/BML), in relation to axial length.
  • To explore the implications of these findings for biometric measurements.

Main Methods:

  • A population-based study using optical coherence tomography (OCT) images from the Beijing Eye Study.
  • Analysis of 366 eyes, examining the location and depth of the PP-RPE/BML on radial and horizontal OCT scans.
  • Correlation analysis to identify factors associated with extrafoveal PP-RPE/BML location.

Main Results:

  • An extrafoveal PP-RPE/BML was observed in a significant proportion of eyes, particularly on radial scans.
  • Higher prevalence of extrafoveal PP-RPE/BML correlated with longer axial length, increased corneal astigmatism, and female sex.
  • Eyes with a steeper curvature of the RPE/BML at the posterior pole had longer axial lengths.

Conclusions:

  • Longer axial length is associated with a more frequent extrafoveal location of the foveola and PP-RPE/BML.
  • This positional shift may be relevant for accurate axial length measurements.
  • An extrafoveal PP-RPE/BML might result from asymmetric enlargement of Bruch's membrane during axial elongation.