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The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity.

Diane N Sayah1,2, Denise Descovich1, Santiago Costantino1,3

  • 1Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec H1T 2M4, Canada.

Ophthalmology Science
|September 10, 2024
PubMed
Summary
This summary is machine-generated.

A study found a strong inverse correlation between pulsatile choroidal volume change (ΔV) and ocular rigidity (OR). A more compliant eye is associated with greater ΔV, suggesting biomechanical interactions influence ocular blood flow.

Keywords:
BiomechanicsBlood flowChoroidGlaucomaOcular rigidity

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Ocular Biomechanics

Background:

  • Ocular rigidity (OR) is a key biomechanical property influencing eye health.
  • Pulsatile choroidal volume change (ΔV) reflects ocular blood flow dynamics.
  • Understanding the relationship between ocular biomechanics and blood flow is crucial for diagnosing and managing eye diseases.

Purpose of the Study:

  • To investigate the relationship between pulsatile choroidal volume change (ΔV) and ocular rigidity (OR).
  • To assess how ocular biomechanics influence pulsatile ocular blood flow.

Main Methods:

  • Prospective cross-sectional study involving 217 participants (235 eyes).
  • Pulsatile choroidal volume change (ΔV) measured using dynamic OCT.
  • Ocular rigidity (OR) measured using invasive and noninvasive optical methods.
  • Correlations assessed in healthy eyes, eyes with glaucoma, and eyes with exudative retinal disease.

Main Results:

  • A significant inverse correlation was found between ΔV and OR (rs = -0.748, P < 0.001) in noninvasive measurements.
  • A more compliant eye (lower OR) was associated with greater ΔV.
  • No significant correlation was observed between ΔV and age, blood pressure, intraocular pressure, axial length, or diagnosis.

Conclusions:

  • An association exists between corneoscleral shell biomechanics and pulsatile ocular blood flow.
  • A more rigid eye may resist pulsatile choroidal expansion.
  • These findings enhance understanding of the dynamic interplay between ocular blood flow and biomechanics in disease pathophysiology.