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Related Concept Videos

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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Nfs1 As A Candidate Prognostic Biomarker For Gastric Cancer Correlated With Immune Infiltrates.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Nfs1 As A Candidate Prognostic Biomarker For Gastric Cancer Correlated With Immune Infiltrates.

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NFS1 as a Candidate Prognostic Biomarker for Gastric Cancer Correlated with Immune Infiltrates.

You Jiang1,2, Wenbo Li1,2, Jun Zhang1

  • 1Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230011, People's Republic of China.

International Journal of General Medicine
|September 10, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Cysteine desulfurase (NFS1) is highly expressed in gastric cancer (GC), indicating a poor prognosis and potential for immunotherapy. NFS1 may serve as a diagnostic and prognostic biomarker for GC patients.

Keywords:
NFS1gastric cancerimmune infiltrationprognostic biomarker

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cysteine desulfurase (NFS1) is implicated in human tumor development.
  • The role of NFS1 in gastric cancer (GC) prognosis and immunity is not well understood.

Purpose of the Study:

  • To investigate the association between NFS1 expression and GC.
  • To evaluate NFS1 as a potential biomarker for GC diagnosis, prognosis, and immunotherapy response.

Main Methods:

  • Analysis of GC data from The Cancer Genome Atlas (TCGA).
  • Utilized Tumor Immune Estimation Resource (TIMER) and Kaplan-Meier Plotter for online analysis.
  • Validation using immunohistochemical testing on clinical samples.

Main Results:

  • NFS1 mRNA and protein levels were significantly elevated in GC tissues compared to normal tissues, with high diagnostic value (AUC=0.793).
  • NFS1 expression correlated with tumor invasion depth, lymph node metastasis, and tumor stage, and predicted poorer prognosis, acting as an independent risk factor.
  • NFS1 was linked to immune-related pathways, positively correlating with M0 macrophages and plasma cells, and negatively with B cells memory, monocytes, and resting mast cells. It also correlated with TMB levels and immunotherapy response.

    • Conclusions:

    • NFS1 may serve as a valuable biomarker for GC diagnosis.
    • NFS1 shows potential in predicting GC patient prognosis and response to immunotherapy.