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Published on: February 16, 2016
Left Ventricular Wall Motion as an Additional Valuable Parameter in Diabetic Patients with Normal Myocardial
Amirhesam Davari1, Fatemeh Jalali-Zefrei1, Bahare Gholami-Chabok1
1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Insights
Diabetes Mellitus (DM) significantly impacts left ventricular wall motion (Wm) in patients with normal Myocardial Perfusion Imaging (MPI), suggesting its use for early diabetic cardiomyopathy detection.
Area of Science:
- Cardiology
- Nuclear Medicine
- Diabetology
Background:
- Gated SPECT is vital for assessing left ventricular function in cardiovascular disease.
- Limited data exists on diabetes mellitus (DM) influence on gated SPECT parameters.
- This study investigates gated SPECT parameters in DM vs. non-DM patients with normal Myocardial Perfusion Imaging (MPI).
Purpose of the Study:
- To assess and compare gated SPECT parameters between diabetic and non-diabetic patients with normal MPI.
- To identify potential subclinical cardiac changes in diabetic patients.
- To explore the independent effect of DM on left ventricular function.
Main Methods:
- Analytical cross-sectional study involving 314 patients (157 DM, 157 non-DM) with normal MPI.
- Comparison of gated SPECT parameters including ejection fraction, volumes, and wall motion.
- Analysis of cardiovascular risk factors like hypertension and dyslipidemia prevalence.
Main Results:
- No significant differences in parameters like ejection fraction, volumes, or wall thickness between DM and non-DM groups.
- Wall motion (Wm) was significantly higher in DM patients compared to non-DM patients (p=0.01).
- The effect of DM on Wm was independent of hypertension status.
Conclusions:
- Left ventricular wall motion (Wm) is a key parameter for early detection and prevention of heart disease in DM patients.
- Elevated Wm may indicate early changes in left ventricular function, signaling the onset of diabetic cardiomyopathy.
- Gated SPECT can reveal subclinical cardiac alterations in diabetic individuals.
Background:
Gated SPECT is an established technique for assessment of left ventricular function in cardiovascular disease patients. However, there is little information about the influence of diabetes mellitus on gated SPECT parameters. This study was established to assess gated SPECT parameters in Diabetes Mellitus (DM) and non-diabetes mellitus (non-DM) patients with normal Myocardial Perfusion Imaging (MPI).
Methods:
In this analytical cross-sectional study, 314 patients (157 DM, 157 non-DM) with normal MPI were enrolled. Prevalence of risk factors for CAD like hypertension (HTN), and dyslipidemia were found to be significantly higher (p <0.01) in DM patients compared to non-DM.
Results:
No statistically significant difference was observed among the TID, ESV, EDV, PFR, TTPF, and Wall Thickness (WT) parameters between DM and non-DM patients. Wall motion (Wm) in DM patients was significantly higher compared to non-DM patients. (3.9 ± 0.51 vs. 2.69 ± 0.48 for DM and non-DM patients, respectively, p-value:0.01). Also, there was no significant difference in Wm in the two groups with and without HTN. This shows the independent effect of DM on the Wm.
Conclusion:
This study believes that the Wm parameter should be noted for the early diagnosis or prevention of heart disease in DM patients. These findings can indicate the gradual changes in the movements of the left ventricle and the beginning of the progression of diabetic cardiomyopathy.
