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Sarcopenia in Children Post Liver Transplant: Development of a Home-Based Video Program to Support Muscle Strength
Amber Hager1, Normand Boule2, Lesley Pritchard3
1Department of Agricultural, Food & Nutritional Sciences, University of Alberta, Edmonton, Canada.
Clinical Transplantation
|September 10, 2024
Summary
Resistance training (RT) is feasible and effective for children post-liver transplant (LTx), improving muscle mass and physical performance. This intervention may help combat sarcopenia in this population.
Area of Science:
- Pediatric transplantation
- Exercise physiology
- Rehabilitation medicine
Background:
- Sarcopenia is a prevalent concern in children following liver transplantation (LTx).
- Resistance training (RT) presents a potential therapeutic strategy to address sarcopenia in pediatric LTx patients.
Purpose of the Study:
- To evaluate the feasibility and impact of a 12-week RT program in children post-LTx.
- To assess changes in skeletal muscle mass (SMM), muscle strength, and physical performance (PP).
- To explore child-parent perspectives on participating in RT.
Main Methods:
- A 12-week progressive RT program using resistance bands was implemented.
- Participants included children aged 6-18 years, both post-LTx and healthy controls (HC).
- Measurements included SMM and adipose tissue via MRI, muscle strength tests, and PP assessments (6-minute walk test [6MWT], timed-up-and-down-stair test [TUDS]).
Main Results:
- LTx children showed significant increases in abdominal SM-index and decreases in visceral adipose tissue-index compared to HC.
- Improvements were observed in 6MWT distance, number of push-ups, and TUDS completion time in the LTx group.
- Adherence and family engagement positively influenced the outcomes; higher thigh muscle-fat content correlated with poorer PP.
Conclusions:
- Resistance training is a feasible and effective intervention for children after liver transplantation.
- RT can potentially mitigate adverse outcomes associated with sarcopenia in pediatric LTx recipients.
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