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Resorbable Microspheres versus Trisacryl Gelatin Microspheres for Uterine Artery Embolization: A Randomized
Kichang Han1, So Yeon Kim1, Man-Deuk Kim1
1From the Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul 03722, Republic of Korea (K.H., M.D.K., J.H.K., G.M.K., S.M., J.P., H.C.K., J.Y.W., T.M.A.D., J.C., D.K.K.); Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea (S.Y.K., J.Y.); and Department of Biomedical Systems Informatics, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea (H.J.S.).
Resorbable microspheres (RMs) and permanent trisacryl gelatin microspheres (TAGMs) show similar effectiveness for uterine artery embolization (UAE) in treating fibroids, with no significant differences in pain or ovarian function. However, RMs led to higher uterine artery recanalization rates.
Area of Science:
- Interventional Radiology
- Gynecologic Surgery
- Vascular Embolization
Background:
- Limited comparative data exist for resorbable microspheres (RMs) versus permanent trisacryl gelatin microspheres (TAGMs) in uterine artery embolization (UAE).
- Understanding the comparative outcomes is crucial for optimizing treatment for symptomatic uterine fibroids.
Purpose of the Study:
- To compare the therapeutic efficacy and clinical outcomes of UAE using RMs versus TAGMs.
- To evaluate differences in pain, ovarian function, fibroid necrosis, and artery recanalization between the two types of embolic agents.
Main Methods:
- A randomized controlled trial involving 60 participants with symptomatic fibroids undergoing UAE.
- Participants were randomized to receive UAE with either RMs or TAGMs.
- Outcomes assessed included pain scores, fentanyl consumption, anti-Mullerian hormone levels, fibroid necrosis via MRI, and uterine artery recanalization.
Main Results:
- No significant differences were found in pain scores, fentanyl consumption, or complete fibroid necrosis between the RM and TAGM groups.
- Serum anti-Mullerian hormone levels showed no significant difference, suggesting similar effects on ovarian function.
- Uterine artery recanalization rates were significantly higher in the RM group (70%) compared to the TAGM group (17%).
Conclusions:
- UAE with RMs is therapeutically comparable to UAE with TAGMs for symptomatic fibroids, with no differences in pain or ovarian function.
- The higher rate of uterine artery recanalization with RMs warrants further investigation regarding long-term implications.
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