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Hepatic clearance measurements and pharmacokinetics
Pharmacology
|January 1, 1979
Summary
This review highlights the importance of accurate hepatic pharmacokinetic models and discusses how to interpret hepatic clearance measurements. It classifies drugs based on their hepatic clearance, aiding in understanding drug behavior in the liver.
Area of Science:
- Pharmacology
- Drug Metabolism
- Liver Physiology
Background:
- Hepatic pharmacokinetics is crucial for understanding drug disposition.
- Accurate interpretation of hepatic clearance measurements is essential for drug development.
- Existing models for hepatic drug clearance require refinement.
Purpose of the Study:
- To emphasize the need for well-defined hepatic pharmacokinetic models.
- To discuss the interpretation of hepatic clearance measurements.
- To outline the pharmacokinetic consequences and classify drugs based on hepatic clearance.
Main Methods:
- Theoretical comparisons of recent approaches.
- Experimental comparisons of recent approaches.
- Review of existing literature on hepatic pharmacokinetics.
Main Results:
- Recent pharmacokinetic modeling approaches were evaluated.
- Methods for interpreting hepatic clearance were discussed.
- A classification of drugs based on hepatic clearance was proposed.
Conclusions:
- Well-defined hepatic pharmacokinetic models are necessary.
- Improved interpretation of hepatic clearance measurements is vital.
- Drug classification by hepatic clearance aids in predicting pharmacokinetic outcomes.