Related Experiment Video

Updated: Jun 13, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

5.3K

The Road Ahead: Advancing Antifungal Vaccines and Addressing Fungal Infections in the Post-COVID World

Xiaolong Gong1, Mohmmad Younus Wani2, Abdullah Saad Al-Bogami2

  • 1Clinical Microbiology and Infectious Diseases, School of Pathology, Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.

ACS Infectious Diseases
|September 10, 2024
PubMed

Insights

Deadly fungal infections surged globally due to COVID-19, worsened by drug resistance. Developing antifungal vaccines and treatments is crucial to combat these severe, often hospital-acquired, infections.

Area of Science:

  • Mycology
  • Immunology
  • Epidemiology

Background:

  • The COVID-19 pandemic has increased deadly fungal infections, particularly mucormycosis, in low-resource settings.
  • Drug-resistant fungal strains and factors like steroid use contribute to rising hospital-acquired fungal infections.
  • Fungi evade immune responses, necessitating novel strategies beyond current antifungal treatments.

Purpose of the Study:

  • To review the global burden of fungal infections and host-pathogen interactions.
  • To explore advancements in antifungal vaccine development.
  • To identify future research directions for combating multidrug-resistant fungal pathogens.

Main Methods:

  • Literature review focusing on global epidemiology of fungal infections.
  • Analysis of host-fungal immunological interactions.
  • Examination of current and emerging antifungal strategies, including vaccines.

Main Results:

  • Increased incidence of severe fungal diseases linked to pandemic conditions and immune compromise.
  • Significant challenges posed by antifungal drug resistance.
  • Evidence supporting the potential of therapeutic vaccination and prophylaxis.

Conclusions:

  • Urgent need for innovative antifungal drugs and vaccines to address high mortality.
  • Understanding host-immune responses is key to developing effective interventions.
  • Continued research is vital for managing the global threat of multidrug-resistant fungi.
Keywords:
antifungal immunityantifungal prophylaxisantifungal vaccinefungal infectionspan-fungal vaccine

More Related Videos

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

14.4K
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

6.9K

Related Concept Videos

Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
146
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
923
Vaccinations01:51

Vaccinations

Overview
44.2K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.9K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.5K