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Related Experiment Video

Updated: Jun 13, 2025

Synovial Fluid Analysis to Identify Osteoarthritis

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

Serum trace elements and osteoarthritis: A meta-analysis and Mendelian randomization study.

Haoyan Shi¹, Haochen Wang¹, Minghao Yu¹

¹Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)

|September 10, 2024

Summary

Serum trace element levels, including copper, manganese, cadmium, and selenium, are associated with osteoarthritis (OA) progression. Elevated serum copper may be a key factor in OA development.

Keywords:

Copper Mendelian Randomization Meta-analysis Osteoarthritis Trace elements

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Last Updated: Jun 13, 2025

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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

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Published on: July 22, 2021

Area of Science:

Biochemistry
Genetics
Epidemiology

Background:

Osteoarthritis (OA) is a degenerative joint disease with complex etiology.
Trace elements (TEs) play crucial roles in biological processes, and their dysregulation may impact OA.
Understanding the relationship between TEs and OA is vital for developing new therapeutic strategies.

Purpose of the Study:

To investigate the correlation between serum TE levels and OA progression.
To explore the potential causal relationship between specific TEs and OA using Mendelian randomization.
To identify key TEs associated with OA for potential therapeutic interventions.

Main Methods:

A systematic review and meta-analysis of observational studies were performed.
Two-sample Mendelian randomization (MR) analysis was employed to assess causality.
Serum TE levels in OA patients were compared to healthy controls.

Main Results:

Meta-analysis showed significant differences in serum copper, manganese, cadmium, and selenium levels between OA patients and controls.
Elevated serum copper (SMD 0.118) and cadmium (SMD 0.227) and decreased manganese (SMD -0.180) and selenium (SMD -0.138) were observed in OA patients.
MR analysis indicated a causal effect of genetically predicted serum copper levels on OA development.

Conclusions:

Serum TE level variations, particularly elevated copper, are associated with OA occurrence.
Copper, manganese, cadmium, and selenium levels are linked to OA.
Further research into TE modulation for OA management is warranted.