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Related Experiment Video

Updated: Jun 13, 2025

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

Post-radiation optic neuropathy.

Edward Margolin¹, Armin Handzic^2,3

¹University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada Edward.margolin@uhn.ca.

Practical Neurology

|September 10, 2024

Summary

This summary is machine-generated.

A patient experienced sequential vision loss after pituitary surgery and radiotherapy. This case highlights post-radiation optic neuropathy, a condition affecting the optic nerve following radiation therapy.

Keywords:

NEUROOPHTHALMOLOGY OPHTHALMOLOGY RADIOTHERAPY

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Area of Science:

Ophthalmology
Neurology
Radiation Oncology

Background:

Pituitary macroadenomas can cause visual disturbances.
Radiotherapy is sometimes used as an adjuvant treatment following surgical resection of pituitary macroadenomas.
Optic neuropathy is a potential complication of radiation therapy near the visual pathway.

Purpose of the Study:

To describe a case of sequential vision loss.
To diagnose post-radiation optic neuropathy.
To discuss the pathophysiology and potential treatment of this condition.

Main Methods:

Case report of a middle-aged man with bilateral vision loss.
Review of medical history, including pituitary macroadenoma resection and radiotherapy.
Magnetic Resonance (MR) imaging of the brain and orbits with contrast.
Cerebrospinal fluid analysis.

Main Results:

The patient developed subacute, painless visual loss in both eyes.
MR imaging revealed enhancement in the prechiasmatic segments of both optic nerves.
A history of pituitary radiotherapy 1.5 years prior was identified.
Diagnosis of post-radiation optic neuropathy was made.

Conclusions:

Post-radiation optic neuropathy can cause severe, sequential vision loss.
Pathophysiology involves radiation-induced endotheliopathy of the optic nerve's vasa nervosum.
Hyperbaric oxygen therapy may be a promising treatment if initiated early.