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Postoperative respiratory difficulties following primary cleft palate repair in infants with Robin sequence versus
Shirley van de Velde1, Merel M Smit1, Robrecht J H Logjes1
1Department of Pediatric Plastic and Reconstructive Surgery, University Medical Center Utrecht, Wilhelmina Children's Hospital, Lundlaan 6, 3584 EA, Utrecht, the Netherlands.
Insights
Infants with Robin sequence (RS), particularly non-isolated RS, face a higher risk of postoperative respiratory difficulties (PRD) after cleft palate repair (CPR). Preoperative palatal plate analysis showed limited predictive value for PRD in these infants.
Area of Science:
- Pediatric Surgery
- Craniofacial Anomalies
- Respiratory Medicine
Background:
- Cleft palate repair (CPR) is a common surgical procedure in infants.
- Postoperative respiratory difficulties (PRD) are a known complication.
- Robin sequence (RS) presents unique challenges due to airway anatomy.
Purpose of the Study:
- Compare PRD incidence after primary CPR between isolated cleft palate (iCP) and Robin sequence (RS) infants.
- Evaluate the utility of preoperative palatal plate analysis in RS infants.
- Identify risk factors for PRD in infants undergoing CPR.
Main Methods:
- Retrospective review of infants undergoing primary CPR from January 2009 to June 2022.
- Inclusion of infants with iCP and RS (further categorized into non-isolated RS [niRS] and isolated RS [iRS]).
- Statistical analysis to compare PRD rates and assess the impact of palatal plate screening.
Main Results:
- Infants with RS exhibited significantly higher PRD rates compared to iCP infants (14/53 vs. 9/74, p=0.04).
- Infants with niRS had a significantly higher risk of PRD versus iCP infants (OR=4.16, p=0.031).
- Preoperative palatal plate screening in RS infants (n=25) revealed no abnormalities and did not alter perioperative management or predict PRD.
Conclusions:
- Infants with niRS are more susceptible to PRD following primary CPR than iRS or iCP infants.
- Postponing CPR in RS infants to avoid PRD showed no clear benefit.
- Preoperative palatal plate analysis has low predictive value for identifying RS infants at risk of PRD.
Abstract:
The study aimed to: (1) compare the occurrence of postoperative respiratory difficulties (PRD) following primary cleft palate repair (CPR) in infants with an isolated cleft palate (iCP) and infants with Robin sequence (RS), and (2) describe the possible benefit of preoperative analysis with palatal plate in infants with RS. All consecutive infants with an iCP and infants with RS who underwent CPR between January 2009 and June 2022 in the Wilhelmina Children's Hospital were retrospectively reviewed. A total of 127 infants were included of which 74 infants with an iCP and 53 infants with RS. The group of infants with RS consisted of 35 infants with non-isolated RS (niRS) and 18 infants with isolated RS (iRS). Significant more PRD were seen in infants with RS compared to infants with an iCP (14/53 versus 9/74; p = 0.04). Especially infants with niRS have a significant higher risk of developing PRD in comparison with infants with an iCP (OR = 4.16, 95% CI [1.17-15.99], p = 0.031). The preoperative palatal plate screening in infants with RS (n = 25) did not show abnormalities and had no effect on the perioperative policy. Within the limitations of this study it seems that infants with niRS are more prone to develop PRD following primary CPR when compared to infants with iRS or an iCP. No clear benefit was found in postponing surgery until 12 months or later in infants with RS to avoid PRD. The preoperative palatal plate screening did not demonstrate signs of UAO in infants with RS that developed PRD. These findings suggest that preoperative analysis with palatal plate has a low predictive value.
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