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Doxycycline-associated acute pancreatitis: a rare adverse effect of a commonly prescribed antibiotic

Melissa Rachel Goldin1, Rachael Petry2, Parul Goyal3

  • 1School of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA melissa.r.goldin@vanderbilt.edu.

BMJ Case Reports
|September 10, 2024
PubMed

Insights

Doxycycline can cause acute pancreatitis, a rare but serious side effect. This case highlights the importance of considering drug-induced pancreatitis in elderly patients, especially those with multiple medications.

Area of Science:

  • Internal Medicine
  • Gastroenterology
  • Pharmacology

Background:

  • Acute pancreatitis is a serious condition with various potential causes.
  • Identifying the specific cause is crucial for effective management.
  • Drug-induced acute pancreatitis is an uncommon but significant etiology.

Observation:

  • An elderly female patient developed acute pancreatitis symptoms after initiating doxycycline therapy.
  • Common causes of pancreatitis were excluded.
  • Doxycycline was identified as the likely causative agent after a thorough medication review.

Findings:

  • Discontinuation of doxycycline led to gradual improvement in the patient's condition.
  • This case underscores doxycycline as a potential cause of drug-induced pancreatitis.
  • Diagnosis can be challenging in polypharmacy settings common in older adults.

Implications:

  • Early recognition of doxycycline-induced pancreatitis can improve patient outcomes.
  • Clinicians should consider drug-induced causes in elderly patients presenting with pancreatitis of unclear etiology.
  • Awareness of this rare complication is vital for appropriate patient care and medication management.
Keywords:
DoxycyclineGastrointestinal systemGeriatric medicinePancreatitisUnwanted effects / adverse reactions

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