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Don't wait, vaccinate: evaluation of routine vaccination administration and reactogenicity in preterm infants
Emily Abdelmessih1, Purnahamsi V Desai1,2, Joanna Tracy1
1NYU Hassenfeld Children's Hospital, New York, NY, USA.
Insights
Administering the 2-month vaccine series at once to preterm infants does not increase cardiorespiratory events. This approach also prevents vaccine schedule interruptions, ensuring timely immunization for vulnerable infants.
Area of Science:
- Neonatal Medicine
- Pediatric Vaccinology
- Public Health
Background:
- Preterm infants are at increased risk for complications following vaccinations.
- Current vaccination schedules may lead to interruptions, potentially compromising immunization efficacy.
- The safety of same-day vaccine administration in preterm infants requires further investigation.
Purpose of the Study:
- To compare the incidence of cardiorespiratory events in preterm infants receiving the 2-month vaccine series administered all at once versus spread over multiple days.
- To identify predictors of cardiorespiratory events in this population.
Main Methods:
- Retrospective cohort study (2019-2022) of preterm neonates receiving 2-month vaccinations.
- Primary outcome: cardiorespiratory events within 48 hours of final vaccine administration.
- Univariate analysis to determine predictors of cardiorespiratory events.
Main Results:
- No significant difference in cardiorespiratory events between same-day and multi-day vaccine administration groups.
- Younger gestational age, lower birth weight, shorter birth length, and baseline cardiorespiratory events predicted severe events.
- Vaccine schedule interruptions were more frequent when administration was spread over multiple days.
Conclusions:
- Same-day administration of the 2-month vaccine series is safe for preterm infants, showing no increased risk of cardiorespiratory events.
- Administering vaccines all at once improves adherence to the vaccination schedule.
- This strategy supports timely and complete immunization in preterm neonates.
Objective:
To evaluate the incidence of cardiorespiratory events in preterm infants when administering the 2-month vaccine series all at once compared to spreading vaccines over multiple days.
Study Design:
This single-center, retrospective cohort study from 2019-2022 included preterm neonates receiving 2-month vaccinations. The primary outcome was incidence of cardiorespiratory events from time of initial vaccine administration up to 48 h after final administration. Univariate analysis was performed to identify predictors of primary outcome.
Results:
There were 127 patients (pre-practice change n1 = 52, post-practice change n2 = 75) included with no difference in the number of cardiorespiratory events between groups. Predictors of severe event included younger gestational age, smaller birth weight, shorter birth length, and greater cardiorespiratory events at baseline. Vaccine schedule interruptions occur more often when administration is spread over multiple days.
Conclusion:
Administration of 2-month vaccinations all at once was not associated with increased cardiorespiratory events and prevents interruptions to vaccine schedule.
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