Association of procalcitonin with voriconazole concentrations: a retrospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Procalcitonin (PCT) levels correlate with voriconazole (VCZ) serum concentrations. Higher PCT may indicate increased VCZ levels, suggesting PCT as a potential biomarker for optimizing voriconazole drug monitoring.
Area Of Science
- Pharmacology
- Clinical Chemistry
- Infectious Diseases
Background
- Inflammation is a known risk factor for voriconazole (VCZ) toxicity.
- Procalcitonin (PCT) is a recognized biomarker for bacterial infections.
- The relationship between PCT and voriconazole trough serum concentrations (VCZ-Cmin) requires further elucidation.
Purpose Of The Study
- To investigate the association between PCT levels and VCZ-Cmin.
- To determine if PCT can serve as a predictive marker for voriconazole drug levels.
Main Methods
- Retrospective cohort study of 147 patients treated with VCZ.
- Collected clinical data and monitored VCZ concentrations from August 2017 to August 2021.
- Utilized multivariate linear regression analysis to assess the association between PCT and VCZ-Cmin.
Main Results
- A significant positive association was found between PCT and VCZ-Cmin (p < 0.001).
- Each increment in PCT was associated with a 0.32 µg/mL increase in VCZ-Cmin (crude model).
- Adjusted models showed VCZ-Cmin increased by 0.21–0.23 µg/mL per PCT increment, indicating a consistent relationship.
Conclusions
- PCT is significantly correlated with VCZ-Cmin.
- PCT demonstrates potential as a valuable biomarker for therapeutic drug monitoring of voriconazole.
- This finding may aid in optimizing VCZ dosing and minimizing toxicity risk.
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