Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MagmaFlow: A desktop platform for artificial intelligence-driven expression analysis.

FEBS open bio·2026

Same author

PTPN2 deficiency amplifies inflammatory signalling and impairs functional maturation of human stem cell-derived islets.

Stem cell research & therapy·2026

Same author

Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates.

Stem cell research & therapy·2025

Same author

Therapeutic potential of stem cell-derived somatic cells to treat metabolic dysfunction-associated steatotic liver disease and diabetes.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2025

Same author

Protocol for CRISPR-Cas12a genome editing of protein tyrosine phosphatases in human pluripotent stem cells and functional β-like cell generation.

STAR protocols·2024

Same author

Commentary: CRISPR gene editing for inherited retinal dystrophies: Towards clinical translation.

Indian journal of ophthalmology·2022

Search research articles

Related Experiment Video

Updated: Jun 13, 2025

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Advances in retina genetics: Progress, potential, and challenges.

Mayank Bansal¹

¹Vitreo-Retinal Surgery, CSIR - Institute of Genomics and Integrative Biology, Sightgenics Research and Fortis Memorial Research Institute, Delhi, India.

Indian Journal of Ophthalmology

|September 11, 2024

Summary

Retinal genetics advances, driven by next-generation sequencing, offer personalized treatments for eye diseases. Challenges in data interpretation and clinical translation remain key areas for future research and collaboration.

More Related Videos

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Related Experiment Videos

Last Updated: Jun 13, 2025

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Recent advancements in retinal genetics are transforming the understanding of retinal conditions.
Key diseases impacted include age-related macular degeneration, diabetic retinopathy, and inherited retinal dystrophies.

Purpose of the Study:

To provide a comprehensive overview of the current state of retinal genetics.
To discuss progress, future directions, and challenges in the field.
To guide ophthalmologists, healthcare professionals, scientists, and policymakers.

Main Methods:

Review of recent literature on retinal genetics.
Highlighting advancements in next-generation sequencing (NGS) for mutation discovery.
Discussion of emerging therapeutic strategies including stem cells, gene augmentation, and CRISPR/Cas9 gene editing.

Main Results:

NGS has significantly accelerated the identification of genetic mutations.
Personalized medicine and targeted therapies for retinal diseases are becoming feasible.
Gene-editing technologies show promise for treating inherited retinal conditions.

Conclusions:

Despite significant progress, challenges in genetic data interpretation and clinical translation persist.
Ethical considerations and the bench-to-bedside gap require attention.
Further research and collaboration are essential to realize the full potential of retinal genetics for improving eye health.