Related Experiment Video
Updated: Aug 5, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
14.3K
Omics research in lymphangioleiomyomatosis: status and challenges
Xinhe Zhang1,2, Song Liu3, Luning Yang1
1Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Expert Review of Respiratory Medicine
|September 11, 2024
Summary
Recent omics research reveals potential new biomarkers for Lymphangioleiomyomatosis (LAM), a rare lung disorder affecting women. Further studies combining various omics approaches are expected to enhance biomarker discovery and understanding of LAM pathogenesis.
Area of Science:
- Biochemistry
- Genetics
- Pulmonology
Background:
- Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disorder primarily affecting women of childbearing age.
- Differential expression of molecules, including vascular endothelial growth factor D (VEGF-D), has been observed in LAM patients compared to healthy individuals, suggesting potential biomarker roles.
Purpose of the Study:
- To review recent advances in omics research (genomics, transcriptomics, proteomics, metabolomics) for Lymphangioleiomyomatosis (LAM) biomarker discovery.
- To retrieve and summarize literature on LAM biomarkers identified through omics techniques over the past decade.
Main Methods:
- Literature search using PubMed and other retrieval tools.
- Systematic review of omics studies related to LAM biomarker discovery published in the last 10 years.
Main Results:
- Identification of various molecules with potential as novel biomarkers for LAM.
- Summary of findings from genomics, transcriptomics, proteomics, and metabolomics studies in LAM.
Conclusions:
- Further research with larger sample sizes is needed to validate potential LAM biomarkers and elucidate disease mechanisms.
- Combining multiple omics methods holds promise for discovering novel biomarkers and advancing understanding of LAM pathogenesis.
Keywords:
Biomarkergenomicslymphangioleiomyomatosismetabolomicsomics researchproteomicstranscriptomicsMore Related Videos
Related Concept Videos
01:22Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
01:22Introduction to the Human Microbiota
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:27Microbiota of the Stomach and Small Intestine
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...