Related Experiment Video
Updated: Aug 8, 2026
Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Experimental models for preclinical research in kidney disease
Jin Miao1,2,3,4, Huanhuan Zhu1,2,3,4, Junni Wang1,2,3,4
1Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine.
Abstract:
Acute kidney injury (AKI) and chronic kidney disease (CKD) are significant public health issues associated with a long-term increase in mortality risk, resulting from various etiologies including renal ischemia, sepsis, drug toxicity, and diabetes mellitus. Numerous preclinical models have been developed to deepen our understanding of the pathophysiological mechanisms and therapeutic approaches for kidney diseases. Among these, rodent models have proven to be powerful tools in the discovery of novel therapeutics, while the development of kidney organoids has emerged as a promising advancement in the field. This review provides a comprehensive analysis of the construction methodologies, underlying biological mechanisms, and recent therapeutic developments across different AKI and CKD models. Additionally, this review summarizes the advantages, limitations, and challenges inherent in these preclinical models, thereby contributing robust evidence to support the development of effective therapeutic strategies.
Insights
This review analyzes preclinical models for acute kidney injury (AKI) and chronic kidney disease (CKD), including rodent models and kidney organoids. It details their development, mechanisms, and therapeutic potential for kidney disease research.
Area of Science:
- Nephrology and Regenerative Medicine
- Preclinical Disease Modeling
Background:
- Acute kidney injury (AKI) and chronic kidney disease (CKD) represent significant global health challenges with high mortality rates.
- Etiologies include renal ischemia, sepsis, drug toxicity, and diabetes mellitus, necessitating advanced research models.
Purpose of the Study:
- To comprehensively review and analyze various preclinical models for AKI and CKD.
- To evaluate construction methodologies, biological mechanisms, and therapeutic advancements in these models.
- To summarize the advantages, limitations, and challenges of current preclinical kidney disease models.
Main Methods:
- Analysis of rodent models for kidney disease research.
- Evaluation of kidney organoid development and applications.
- Review of therapeutic strategies investigated in preclinical AKI and CKD models.
Main Results:
- Rodent models are established tools for discovering kidney therapeutics.
- Kidney organoids represent a promising advancement for studying kidney diseases.
- The review synthesizes data on model construction, mechanisms, and therapeutic outcomes.
Conclusions:
- Preclinical models are crucial for understanding kidney disease pathophysiology and developing treatments.
- A thorough understanding of model strengths and weaknesses is essential for advancing therapeutic strategies.
- This review provides evidence to guide the development of effective interventions for AKI and CKD.
Related Concept Videos
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
01:16Clinical Trials
There are four phases in a clinical trial. A phase one...