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Updated: Aug 8, 2026
09:16
Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
17.6K
Experimental models for preclinical research in kidney disease
Jin Miao1,2,3,4, Huanhuan Zhu1,2,3,4, Junni Wang1,2,3,4
1Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine.
Zoological Research
|September 11, 2024
Summary
This review analyzes preclinical models for acute kidney injury (AKI) and chronic kidney disease (CKD), including rodent models and kidney organoids. It details their development, mechanisms, and therapeutic potential for kidney disease research.
Area of Science:
- Nephrology and Regenerative Medicine
- Preclinical Disease Modeling
Background:
- Acute kidney injury (AKI) and chronic kidney disease (CKD) represent significant global health challenges with high mortality rates.
- Etiologies include renal ischemia, sepsis, drug toxicity, and diabetes mellitus, necessitating advanced research models.
Purpose of the Study:
- To comprehensively review and analyze various preclinical models for AKI and CKD.
- To evaluate construction methodologies, biological mechanisms, and therapeutic advancements in these models.
- To summarize the advantages, limitations, and challenges of current preclinical kidney disease models.
Main Methods:
- Analysis of rodent models for kidney disease research.
- Evaluation of kidney organoid development and applications.
- Review of therapeutic strategies investigated in preclinical AKI and CKD models.
Main Results:
- Rodent models are established tools for discovering kidney therapeutics.
- Kidney organoids represent a promising advancement for studying kidney diseases.
- The review synthesizes data on model construction, mechanisms, and therapeutic outcomes.
Conclusions:
- Preclinical models are crucial for understanding kidney disease pathophysiology and developing treatments.
- A thorough understanding of model strengths and weaknesses is essential for advancing therapeutic strategies.
- This review provides evidence to guide the development of effective interventions for AKI and CKD.
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