Role of flavonoids in inhibiting triple-negative breast cancer

Area of Science:

• Oncology
• Pharmacology
• Natural Products

Background:

• Triple-negative breast cancer (TNBC) presents a significant clinical challenge due to high rates of metastasis and recurrence.
• Metastasis and recurrence in TNBC are strongly associated with increased patient mortality.
• Current treatment options for advanced TNBC are limited, necessitating novel therapeutic strategies.

Purpose of the Study:

• To review the mechanisms by which flavonoids inhibit TNBC.
• To explore the potential of flavonoids from traditional Chinese medicine as a therapeutic intervention for TNBC.
• To consolidate knowledge on flavonoid-based strategies for preventing TNBC progression and metastasis.

Main Methods:

• Literature review of studies on flavonoids and their effects on TNBC.
• Analysis of mechanisms including apoptosis induction, cell cycle arrest, and anti-angiogenesis.
• Examination of flavonoid impact on extracellular matrix degradation, aerobic glycolysis, and tumor microenvironment.

Main Results:

• Flavonoids demonstrate multi-target and coordinated intervention capabilities against TNBC.
• Key inhibitory mechanisms include promoting apoptosis and blocking cell cycle progression.
• Flavonoids also regulate extracellular matrix, inhibit angiogenesis and aerobic glycolysis, and improve the tumor microenvironment.

Conclusions:

• Flavonoids represent a promising class of compounds for the pharmacological intervention of TNBC.
• Their multifaceted action provides a strong basis for developing novel treatments to combat TNBC metastasis and recurrence.
• Further research into flavonoids could lead to improved outcomes for patients with advanced triple-negative breast cancer.