Sex-Specific Elevated Fasting Glucose in Patients with Major Depressive Disorder
Neha P Prathivadi1, Badari Birur2, Li Li2
1Department of Psychology, The University of Texas at Austin, Austin, TX, 78712, USA.
Journal of Diabetes and Treatment
|September 11, 2024
Summary
Major Depressive Disorder (MDD) and prediabetes risk are linked, particularly in women. Elevated fasting glucose and cortisol in females with MDD suggest potential biomarkers for early intervention.
Area of Science:
- Endocrinology
- Psychiatry
- Metabolic Health
Background:
- Major Depressive Disorder (MDD) is a prevalent mental health condition.
- Prediabetes is a growing public health concern with significant long-term risks.
- The interplay between MDD and prediabetes, especially sex-specific associations, requires further investigation.
Purpose of the Study:
- To investigate the sex-specific relationship between Major Depressive Disorder (MDD) and prediabetes.
- To explore potential underlying pathways, including cortisol levels, linking MDD and prediabetes.
- To identify potential biomarkers for prediabetes risk in individuals with MDD.
Main Methods:
- 168 participants were enrolled, with 142 completing the study.
- Participants were categorized into groups with and without MDD.
- Oral Glucose Tolerance Tests (OGTT) and serum cortisol levels were measured; data analyzed using t-tests, chi-square, and covariance analysis.
Main Results:
- No significant differences in fasting glucose, post-prandial glucose, or insulin sensitivity were found between overall MDD and control groups.
- Stratified analysis revealed higher fasting glucose and cortisol levels in female participants with MDD compared to female controls.
- Fasting glucose positively correlated with depression severity in females with MDD, a pattern not observed in males.
Conclusions:
- Females with MDD exhibit a heightened risk for prediabetes, potentially mediated by cortisol.
- Fasting glucose and cortisol levels may serve as valuable biomarkers for identifying prediabetes in females with MDD.
- Early identification and intervention for prediabetes in females with MDD can lead to improved health outcomes.
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