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  11. Relationship Of Fibroblast Growth Factor 21, Klotho, And Diabetic Retinopathy: A Meta-analysis

Relationship of fibroblast growth factor 21, Klotho, and diabetic retinopathy: a meta-analysis

Yanhua Jiang1, Weilai Zhang1, Yao Xu2

  • 1Department of Ophthalmology, Fourth People's Hospital of Shenyang, Shenyang, China.

Frontiers in Endocrinology
|September 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Fibroblast growth factor 21 (FGF21) levels are higher in diabetic retinopathy (DR) patients, while Klotho levels are lower. Understanding FGF21

Area of Science:

  • Endocrinology
  • Ophthalmology
  • Metabolic Diseases

Background:

  • Diabetic retinopathy (DR) is a severe complication of diabetes.
  • Fibroblast growth factor 21 (FGF21) and Klotho are implicated in DR pathogenesis.
  • The precise roles of FGF21 and Klotho in DR remain debated.

Conclusions:

  • This meta-analysis provides the first systematic evaluation of FGF21 and Klotho in DR.
  • Elevated FGF21 and reduced Klotho are associated with diabetic retinopathy.
  • Further research into FGF21's role may offer new therapeutic strategies for DR.
Keywords:
DRFGF21Klothodiabetic retinopathy

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fibroblast growth factor 21