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Delayed-type hypersensitivity responses induced by bovine colostral components.

J K Radosevich, G H Scott, G B Olson

    American Journal of Veterinary Research
    |April 1, 1985
    PubMed
    Summary
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    Transfer factor substances from cows effectively transferred cell-mediated immunity across species. Bovine colostrum components are crucial for passive immunity transfer in newborns, supporting cell-mediated immune responses.

    Area of Science:

    • Immunology
    • Veterinary Medicine
    • Cell-Mediated Immunity

    Background:

    • Transfer factors are crucial for immune system regulation.
    • Bovine colostrum is a rich source of immune components.
    • Cell-mediated immunity plays a vital role in host defense.

    Purpose of the Study:

    • To investigate the role of transfer factor-type substances from bovine colostrum in passive immunity.
    • To determine the effectiveness of these substances in transferring delayed-type hypersensitivity across species.
    • To assess the impact of maternal sensitization age on transfer factor efficacy.

    Main Methods:

    • Extraction of transfer factor-type substances from bovine leukocytic cells and colostrum.
    • Administration of these substances to recipient species to assess passive transfer.

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  • Evaluation of delayed-type hypersensitivity responses as a measure of immune transfer.
  • Analysis of colostrum from dams sensitized at different ages (3 and 9 months).

    • Main Results:

    • Transfer factor-type substances facilitated effective passive transfer of delayed-type hypersensitivity across species barriers.
    • Passive transfer of Brucella abortus sensitivity was consistently achieved using components from both peripheral blood and colostrum.
    • Colostral components transferred cell-mediated immunity as early as two days postpartum.
    • Maternal sensitization age did not significantly affect the regularity of passive transfer.

    Conclusions:

    • Bovine colostrum contains crucial components for the passive transfer of cell-mediated immunity.
    • Transfer factor-type substances are effective in establishing passive immunity across species.
    • Early postpartum colostrum is vital for neonatal immune development.