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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Viral Infection and Ischemic Stroke: Emerging Trends and Mechanistic Insights
Michael Clarke1, Sarina Falcione2, Roobina Boghozian2
1Faculty of Medicine and Dentistry Department of Medical Microbiology and Immunology University of Alberta Edmonton AB Canada.
Journal of the American Heart Association
|September 11, 2024
Summary
Viral infections like influenza and COVID-19 may increase ischemic stroke risk. This review explores viral mechanisms, host interactions, and systemic changes contributing to stroke incidence, highlighting the need for further research.
Area of Science:
- Infectious Diseases
- Neurology
- Cardiovascular Science
Background:
- Population studies suggest a link between viral infections and ischemic stroke risk.
- The precise mechanisms underlying this association remain largely unknown.
- Several viral diseases, including influenza, COVID-19, herpesviruses, and hepatitis C, are implicated.
Purpose of the Study:
- To review epidemiological evidence linking viral infections to stroke incidence.
- To examine virus-host interactions relevant to stroke pathogenesis.
- To evaluate systemic changes during viral infection that may predispose to ischemic stroke.
Main Methods:
- Literature review of epidemiological studies.
- Analysis of virus-host interactions impacting vascular function, inflammation, and thrombosis.
- Evaluation of systemic physiological changes during viral infections.
Main Results:
- Viral infections can directly affect vascular function, promote inflammation, and induce thrombosis.
- Systemic alterations in blood pressure, coagulation, and lipid metabolism during infection can increase stroke risk.
- Evidence supports the role of influenza, COVID-19, chronic herpesvirus, and hepatitis C in stroke risk.
Conclusions:
- Further research is crucial to elucidate the exact mechanisms linking viral infections and stroke.
- Understanding these mechanisms will enable the development of targeted stroke prevention strategies.
- Interventions aimed at mitigating viral infection-related stroke risk are needed.
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