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Occult checkpoint inhibitor myocarditis during adjuvant nivolumab plus ipilimumab: a smoldering but severe toxicity

Dimitrios Bafaloukos1, Ioanna Gazouli1, Aikaterini Bousmpoukea1

  • 11st Medical Oncology Department, Neon Faliron, Athens.

Immunotherapy
|September 11, 2024
PubMed

Checkpoint inhibitor myocarditis is a rare but life-threatening toxicity of immunotherapy, occasionally manifesting as persistent troponin elevation. Dual checkpoint blockade with ipilimumab and nivolumab has been found to induce immune-related myocarditis in patients with metastatic melanoma. We herein report a case of smoldering immune-related myocarditis in a 54-year-old male after a single infusion of nivolumab plus ipilimumab as adjuvant treatment for completely resected stage IV melanoma. High-dose steroid treatment resulted in decrease in the levels of cardiac enzymes, without any major complications.

Keywords:
immune-relatedimmunotherapyipilimumabmelanomamyocarditisnivolumabsteroid treatmenttoxicity

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