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Related Experiment Videos

Vancomycin treatment for enterococcal meningitis.

S L Barriere, L I Lutwick, R A Jacobs

    Archives of Neurology
    |July 1, 1985
    PubMed
    Summary
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    Enterococcal central nervous system infections are challenging, especially in penicillin-allergic patients. Vancomycin combined with an aminoglycoside offers a viable treatment option for these serious infections.

    Area of Science:

    • Infectious Diseases
    • Neurology
    • Pharmacology

    Background:

    • Enterococcal infections, particularly those affecting the central nervous system (CNS), are clinically significant but infrequently reported.
    • Limited data exists on treating CNS enterococcal infections in patients with penicillin allergies.

    Observation:

    • Two cases of meningitis caused by enterococci were treated.
    • One case involved a concurrent brain abscess.
    • Both patients had a documented history of severe penicillin sensitivity.

    Findings:

    • Treatment with vancomycin hydrochloride and an aminoglycoside was effective in both cases.
    • This combination therapy demonstrated success in managing severe enterococcal CNS infections.

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    Implications:

    • Vancomycin and aminoglycoside combination therapy is a recommended approach for enterococcal CNS infections.
    • This treatment strategy provides a crucial alternative for penicillin-allergic individuals facing these infections.