Sex and Age Influence the Relationship Between Serum Creatinine/Cystatin C and Carotid Plaque in Patients With Type 2 Diabetes Mellitus
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View abstract on PubMed
Summary
This summary is machine-generated.The serum creatinine/cystatin C ratio (CCR) is a significant predictor of carotid plaque in type 2 diabetes mellitus (T2DM). Lower CCR levels indicate a higher risk, particularly in men and individuals under 65.
Area Of Science
- Cardiovascular Medicine
- Endocrinology
- Nephrology
Background
- Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular disease, including carotid plaque.
- The serum creatinine/cystatin C ratio (CCR) is a marker of kidney function and may reflect systemic vascular health.
- Understanding factors influencing carotid plaque in T2DM is crucial for risk stratification and prevention.
Purpose Of The Study
- To investigate the association between the serum creatinine/cystatin C ratio (CCR) and carotid plaque in patients with T2DM.
- To examine the influence of sex and age on this association.
- To identify CCR as a potential independent predictor of carotid plaque in T2DM.
Main Methods
- Cross-sectional study of 1429 patients with T2DM.
- Carotid plaque status determined by cervical vascular ultrasound.
- Comparison of demographic and biochemical data between plaque and non-plaque groups.
- Multivariate binary logistic regression analysis to identify independent predictors.
Main Results
- The CCR was an independent predictor of carotid plaque in T2DM patients (adjusted OR: 1.681).
- A significant association between decreased CCR and increased carotid plaque risk was observed in men with T2DM.
- An association between CCR and carotid plaque was also found in T2DM patients younger than 65 years.
Conclusions
- The serum creatinine/cystatin C ratio (CCR) is strongly associated with carotid plaque risk in T2DM.
- CCR is an independent risk factor for carotid plaque, particularly in T2DM men and individuals under 65.
- CCR may serve as a valuable biomarker for assessing cardiovascular risk in T2DM.
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