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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Related Experiment Video

Updated: Jun 13, 2025

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
10:32

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Platelet transfusion.

Allison Mo1,2,3, Erica Wood1,2, Zoe McQuilten1,2,4

  • 1Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University.

Current Opinion in Hematology
|September 11, 2024
PubMed
Summary

Platelet transfusions are life-saving but require appropriate use due to rising demand and limited resources. Recent trials show efficacy in some cases, but risks and optimal usage in various patient groups require further investigation.

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Related Experiment Videos

Last Updated: Jun 13, 2025

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Clinical Research

Background:

  • Platelet transfusions are critical for managing bleeding but face increasing demand.
  • Platelets are a valuable and costly resource, necessitating judicious use.
  • Understanding the evidence base for platelet transfusion is vital for appropriate clinical application.

Purpose of the Study:

  • To explore the evidence supporting platelet transfusions in diverse clinical scenarios.
  • To review recent research on the efficacy and risks of platelet transfusions.
  • To discuss optimal strategies for platelet utilization and risk mitigation.

Main Methods:

  • Review of recent randomized clinical trials.
  • Analysis of observational and clinical studies.
  • Exploration of emerging technologies like cold-stored platelets.

Main Results:

  • Platelet transfusions demonstrate efficacy in specific contexts but can be detrimental in others.
  • Risks include transfusion reactions, bacterial contamination, and refractoriness.
  • Alternative strategies like tranexamic acid and thrombopoietin receptor agonists show promise.

Conclusions:

  • Platelet transfusions offer benefits but optimal use remains unclear in many situations.
  • Potential detrimental effects necessitate careful consideration of transfusion necessity.
  • Further clinical trials are essential to define optimal platelet transfusion strategies for different patient populations.