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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Secretory Carcinoma of the Breast: Radiologic-Pathologic Correlation.

Pamela Boustros1, Lilia Maria Sanchez2, Louis Gaboury2

  • 1Department of Radiology, University of Montreal, Montreal, QC, Canada.

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|September 11, 2024
PubMed
Summary

Secretory carcinoma, a rare invasive breast cancer, typically presents as a slow-growing lump. Most cases, especially those with ETV6::NTRK3 gene fusion, show an indolent course and favorable prognosis.

Keywords:
ETV6::NTRK3 gene fusionjuvenile breast carcinomasalivary gland-like tumorsecretory carcinoma

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Secretory carcinoma is a rare, low-grade invasive breast carcinoma.
  • While most common in pediatric patients, it is predominantly diagnosed in adults.
  • Presents as a slow-growing, painless lump with nonspecific imaging findings.

Purpose of the Study:

  • To review the key characteristics, diagnosis, and prognosis of secretory carcinoma.
  • To highlight the genetic underpinnings, specifically the ETV6::NTRK3 gene fusion.
  • To discuss treatment strategies in relation to other invasive breast carcinomas.

Main Methods:

  • Histopathological analysis revealing characteristic secretions.
  • Genetic testing to identify the t(12;15)(p13;q25) translocation and ETV6::NTRK3 gene fusion.
  • Review of clinical presentation, imaging, and patient outcomes.

Main Results:

  • Secretory carcinomas exhibit periodic acid-Schiff positive secretions and mild nuclear pleomorphism.
  • Over 80% of cases harbor the ETV6::NTRK3 gene fusion.
  • Generally demonstrates an indolent course with better prognosis than invasive breast carcinoma of no special type.

Conclusions:

  • Secretory carcinoma is a distinct breast cancer subtype with a generally favorable prognosis.
  • Prognosis is linked to younger age, smaller tumor size, and limited lymph node involvement.
  • Treatment is similar to other invasive breast cancers, with potential for targeted therapy in fusion-positive cases.