Real-world trends in the use of maintenance therapy in ovarian cancer across the United States from 2017 to 2021
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View abstract on PubMed
Summary
This summary is machine-generated.Most ovarian cancer patients do not receive maintenance therapy (MT) after chemotherapy. Factors like age, comorbidities, and location influence MT use, impacting patient decisions and outcomes.
Area Of Science
- Oncology
- Real-world evidence
- Cancer treatment trends
Background
- Maintenance therapy (MT), including poly(ADP-ribose) polymerase inhibitors (PARPi) and bevacizumab, is a key treatment strategy for ovarian cancer.
- Understanding real-world utilization patterns of MT following platinum-based chemotherapy is crucial for optimizing patient care.
Purpose Of The Study
- To assess the real-world trends in the utilization of maintenance therapy (MT) among U.S. ovarian cancer patients post-platinum-based chemotherapy.
- To identify demographic and clinical factors associated with MT use and evaluate its impact on patient outcomes.
Main Methods
- Analysis of de-identified Medicare and commercial claims data (January 2010–March 2021).
- Inclusion of 6339 ovarian cancer patients who received platinum-based chemotherapy and MT.
- Utilized multivariable logistic and Cox proportional hazards regression to analyze MT use and associated factors.
Main Results
- Only 31.5% of patients received MT; bevacizumab and PARPi use increased significantly from 2017-2020.
- Higher comorbidity index (OR: 1.46) and treatment in the South (for PARPi) were associated with MT use.
- Bevacizumab use, alone or with PARPi, was linked to a higher risk of death (HR: 2.02 and 1.66, respectively).
Conclusions
- The majority of ovarian cancer patients do not receive maintenance therapy after chemotherapy.
- Patient age, comorbidity status, and geographic region significantly influence MT utilization.
- Further research is needed to understand real-world outcomes and support informed, value-based treatment decisions.
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