A Simple Frailty Index Predicts Inhospital Mortality

Comparing frailty models in different settings that predict inhospital mortality might modify patient disposition and treatment, but models are often complex.

In the following study, we selected all acutely admitted adult patients in 2020-2021 to the three internal medicine departments at a regional 400-bed hospital. We attempt to determine (a) if a new scale (Laniado-4 scale) that includes only three yes/no questions derived from the Norton scale and the presence of a urinary catheter performs as well as the graded Norton scale (including all five domains), in predicting inhospital mortality and (b) to determine the predictive value of a simple frailty index that includes the new scale as well as categories of age, serum albumin, and creatinine values. We calculated odds ratios with 95% confidence intervals and c-statistics for the various models predicting inhospital mortality.

The mean patient age was 73 ± 19 years, and 49.1% (5,665/11,542) were males. A Laniado-4 scale performed better than the Norton scale for predicting inhospital mortality. A simple frailty index ranging from 0 to ≥8 points was associated with rates of inhospital mortality that increased from 0 to 37.7%, with an odds ratio of 2.13 (2.03-2.25) per 1 index point. The c-statistic was 0.887 (0.881-0.893).

We conclude the Laniado-4 scale performed better than the Norton scale in predicting inhospital mortality and that a simple frailty index that included the 4-question scale and categories of age, serum creatinine, and serum albumin performed as well or better than more complicated models.