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Logistic regression analysis and machine learning for predicting post-stroke gait independence: a retrospective

Yuta Miyazaki1,2,3, Michiyuki Kawakami4,5, Kunitsugu Kondo1,2

  • 1Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan.

Scientific Reports
|September 11, 2024
PubMed
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Logistic regression analysis (LR) shows comparable predictive accuracy to machine learning (ML) algorithms for predicting gait independence in subacute stroke survivors. LR remains a practical choice due to its simplicity and interpretability.

Area of Science:

  • Rehabilitation Medicine
  • Medical Informatics
  • Biostatistics

Background:

  • Predicting gait independence is crucial for subacute stroke patients' recovery.
  • Machine learning (ML) models are increasingly explored for clinical prediction tasks.
  • Traditional statistical models like logistic regression (LR) are widely used.

Purpose of the Study:

  • To compare the predictive accuracy of ML algorithms against LR for gait independence in stroke survivors.
  • To determine if ML offers superior prediction compared to LR in this patient population.

Main Methods:

  • Developed prediction models using LR and five ML algorithms (Decision Tree, Support Vector Machine, Artificial Neural Network, Ensemble Learning, k-Nearest Neighbor).
  • Utilized Functional Independence Measure sub-items to assess walking ability.
Keywords:
Gait independenceLogistic regressionMachine learningPrediction modelsStroke

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  • Evaluated model performance using Area Under the Receiver Operating Characteristic Curve (AUC) and other metrics (accuracy, precision, recall, F1 score, specificity).
  • Main Results:

    • The Decision Tree algorithm showed significantly lower predictive accuracy (AUC=0.812).
    • LR (AUC=0.895) demonstrated comparable predictive accuracy to other ML models (AUCs 0.893-0.903).
    • No substantial differences in other performance metrics were observed between LR and ML algorithms.

    Conclusions:

    • LR provides similar predictive accuracy for gait independence as advanced ML algorithms in subacute stroke patients.
    • LR's interpretability and computational simplicity make it a viable and practical tool for clinical use.
    • The Decision Tree algorithm was found to be less accurate for this specific prediction task.