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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Computational Neuroscience

Background:

  • Perceptual decisions link sensory input to actions through evidence integration.
  • The orchestration of sensory processing, evidence accumulation, and motor control across brain areas remains poorly understood.

Purpose of the Study:

  • To investigate how brain-wide neural activity orchestrates transformations from sensory input to action execution during decision-making.
  • To map the flow of information across brain regions during learned perceptual decisions.

Main Methods:

  • Recorded brain-wide neural activity in mice performing a visual evidence-reporting task.
  • Analyzed neural population dynamics related to evidence integration, movement preparation, and execution.

Main Results:

  • Evidence integration emerged across widespread brain areas, driving movement-preparatory activity.
  • Visual information transformed from transient sensory responses to sustained representations supporting parallel evidence accumulation.
  • Shared population activity encoded evidence and movement preparation, distinct from movement execution.
  • Evidence integration timescales were task-experience dependent, not intrinsic to brain regions.

Conclusions:

  • Learning aligns evidence accumulation with action preparation across numerous brain regions.
  • Decision-making involves highly distributed and parallelized sensorimotor transformations.
  • A brain-wide framework is proposed for understanding how sensory evidence guides actions.