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Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with

Guoliang Wei1, Bin Li2, Hao Wang2

  • 1Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China. weiguoliangmz@126.com.

BMC Cardiovascular Disorders
|September 11, 2024
PubMed

Insights

The APOE ɛ3/ɛ4 genotype is an independent risk factor for coronary atherosclerosis in hypertensive patients, alongside overweight, advanced age, smoking, diabetes, and hyperlipidemia.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Apolipoprotein E (APOE) gene polymorphisms are linked to coronary atherosclerosis and hypertension.
  • The specific role of APOE polymorphisms in coronary atherosclerosis risk among hypertensive individuals remains unclear.

Purpose of the Study:

  • To investigate the association between APOE gene polymorphisms and the susceptibility to coronary atherosclerosis in patients with hypertension.

Main Methods:

  • Retrospective analysis of 1713 hypertensive patients.
  • Genotyping of APOE rs429358 and rs7412 polymorphisms.
  • Statistical analysis to determine the relationship between APOE genotypes and coronary atherosclerosis risk.

Main Results:

  • The APOE ɛ3/ɛ4 genotype frequency was significantly higher in hypertensive patients with coronary atherosclerosis (16.4%) compared to controls (10.9%).
  • Independent risk factors identified include overweight (BMI ≥ 24.0 kg/m²), advanced age (≥ 65 years), smoking history, diabetes mellitus, and hyperlipidemia.
  • APOE ɛ3/ɛ4 genotype was significantly associated with an increased risk of coronary atherosclerosis (OR: 1.514, 95% CI: 1.133-2.024).

Conclusions:

  • Overweight, advanced age, smoking, diabetes mellitus, and the APOE ɛ3/ɛ4 genotype are independent risk factors for coronary atherosclerosis in hypertensive patients.
  • These findings highlight the importance of genetic predisposition, specifically the APOE ɛ3/ɛ4 genotype, in the development of coronary atherosclerosis within the hypertensive population.
Abstract

Keywords:
APOECoronary atherosclerosisHypertensionSusceptibility

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