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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Roadmap to a Global Template for Implementation of Ototoxicity Management for Cancer Treatment
Katharine Fernandez1, Alex Hoetink2,3,4,5, Dawn Konrad-Martin6,7
1Division of Intramural Research, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA.
Abstract:
Ototoxicity is among the adverse events related to cancer treatment that can have far-reaching consequences and negative impacts on quality-of-life for cancer patients and survivors of all ages. Ototoxicity management (OtoM) comprises the prevention, diagnosis, monitoring, and treatment, including rehabilitation and therapeutic intervention, of individuals who experience hearing loss, tinnitus, or balance/vestibular difficulties following exposures to ototoxic agents, including platinum chemotherapy (cisplatin, carboplatin) and cranial radiation. Despite the well-established physical, socioeconomic, and psychological consequences of hearing and balance dysfunction, there are no widely adopted standards for clinical management of cancer treatment-related ototoxicity. Consensus recommendations and a roadmap are needed to guide development of effective and feasible OtoM programs, direct research efforts, address the needs of caregivers and patients at all stages of cancer care and survivorship. Here we review current evidence and propose near-term to longer-term goals to advance OtoM in five strategic areas: (1) beneficiary awareness, empowerment, and engagement, (2) workforce enhancement, (3) program development, (4) policy, funding, and sustainability, and (5) research and evaluation. The goal is to identify needs and establish a roadmap to guide worldwide adoption of standardized OtoM for cancer treatment and improved outcomes for patients and survivors.
Insights
Cancer treatment can cause hearing and balance problems. This study proposes a roadmap for ototoxicity management (OtoM) to improve patient quality-of-life through standardized care.
Area of Science:
- Oncology
- Audiology
- Otolaryngology
Background:
- Ototoxicity, a side effect of cancer treatments like chemotherapy and radiation, significantly impacts patient quality-of-life.
- Hearing loss, tinnitus, and vestibular dysfunction are common consequences, yet standardized clinical management is lacking.
- The physical, socioeconomic, and psychological effects necessitate a structured approach to ototoxicity management (OtoM).
Purpose of the Study:
- To review current evidence on cancer treatment-related ototoxicity.
- To propose a roadmap for developing and implementing standardized OtoM programs.
- To address the needs of patients, survivors, and caregivers throughout cancer care.
Main Methods:
- Review of existing evidence on ototoxicity and its management.
- Identification of strategic areas for advancing OtoM.
- Proposal of near-term and longer-term goals for OtoM implementation.
Main Results:
- Lack of widely adopted standards for clinical management of cancer treatment-related ototoxicity.
- Identification of five strategic areas to advance OtoM: beneficiary engagement, workforce enhancement, program development, policy/funding, and research.
- A need for consensus recommendations and a roadmap to guide OtoM development and adoption.
Conclusions:
- Standardized OtoM is crucial for improving outcomes for cancer patients and survivors.
- A strategic roadmap is proposed to guide the worldwide adoption of OtoM.
- Multifaceted efforts are required to integrate effective OtoM into cancer care.
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