Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Research Domains
  1. Home
  3. Research Domains

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Abnormal Proliferation02:23

Abnormal Proliferation

4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Upregulation Of Cks2 In Immunosuppressive Cells Is Associated With Metastasis And Poor Prognosis In Prostate Cancer: A Single-cell Rna-sequencing Analysis.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Upregulation Of Cks2 In Immunosuppressive Cells Is Associated With Metastasis And Poor Prognosis In Prostate Cancer: A Single-cell Rna-sequencing Analysis.

    • Related Experiment Video

    Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
    12:13

    Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

    Published on: November 19, 2019

    6.8K

    Upregulation of CKS2 in immunosuppressive cells is associated with metastasis and poor prognosis in prostate cancer: a single-cell RNA-sequencing analysis.

    Xiaoxing Liang1,2, Renlun Huang1,2, Xinyue Ping3

    • 1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

    Translational Cancer Research
    |September 12, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    The study identified CKS2 as a key gene promoting prostate cancer (PCa) bone metastasis by creating an immunosuppressive tumor microenvironment. Targeting CKS2 may prevent PCa spread and improve patient outcomes.

    Keywords:
    CKS2bone metastasisprostate cancer (PCa)single-cell RNA-sequencing analysis (single-cell RNA-seq analysis)

    More Related Videos

    A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
    07:41

    A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

    Published on: March 8, 2022

    2.4K
    miRNA Expression Analyses in Prostate Cancer Clinical Tissues
    11:29

    miRNA Expression Analyses in Prostate Cancer Clinical Tissues

    Published on: September 8, 2015

    10.8K

    Related Experiment Videos

    Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
    12:13

    Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

    Published on: November 19, 2019

    6.8K
    A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
    07:41

    A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

    Published on: March 8, 2022

    2.4K
    miRNA Expression Analyses in Prostate Cancer Clinical Tissues
    11:29

    miRNA Expression Analyses in Prostate Cancer Clinical Tissues

    Published on: September 8, 2015

    10.8K

    Area of Science:

    • Oncology
    • Cancer Biology
    • Immunology

    Background:

    • Prostate cancer (PCa) metastasis, particularly to bone, significantly worsens patient prognosis.
    • The tumor microenvironment, especially its immunosuppressive aspects, is crucial in facilitating PCa bone metastasis.
    • Understanding the molecular mechanisms driving this process is vital for developing effective therapeutic strategies.

    Purpose of the Study:

    • To investigate how an immunosuppressive microenvironment promotes PCa metastasis and impacts patient prognosis.
    • To identify candidate oncogenes involved in PCa bone metastasis.
    • To develop a prognostic model for identifying key target genes.

    Main Methods:

    • Utilized Gene Expression Omnibus (GEO) database for candidate oncogene identification.
    • Developed a prognostic model to pinpoint target genes associated with PCa metastasis.
    • Employed single-cell RNA sequencing and pan-cancer analysis to assess gene localization and oncogenic potential.

    Main Results:

    • Identified 51 differentially expressed genes in metastatic vs. non-metastatic PCa.
    • CKS2 emerged as the most significant gene linked to poor prognosis and PCa bone metastasis.
    • CKS2 expression correlated with an immunosuppressive microenvironment, reduced immune cell infiltration, and osteoclast activity, and was overexpressed across multiple tumor types.

    Conclusions:

    • CKS2 plays a critical role in promoting PCa bone metastasis via an immunosuppressive microenvironment.
    • CKS2 is a potential oncogene with implications across various cancers.
    • CKS2 represents a promising therapeutic target for preventing prostate cancer metastasis.