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Malakoplakia in a Transplanted Liver.

Zaid Ansari¹, Akram Ahmad¹, Pablo A Bejarano²

¹Department of Gastroenterology and Hepatology, Cleveland Clinic, Weston, FL.

ACG Case Reports Journal

|September 12, 2024

Summary

This summary is machine-generated.

Malakoplakia, a rare disorder, was found in an adult liver transplant recipient. This case highlights malakoplakia in a transplanted liver, presenting as persistent microabscesses.

Keywords:

Malakoplakia liver abscess liver mass liver transplant

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Area of Science:

Histiocytic disorders
Transplant medicine
Hepatology

Background:

Malakoplakia is a rare acquired histiocytic disorder.
It typically affects the urinary bladder.
Eight cases of hepatic malakoplakia have been previously reported.

Observation:

A 63-year-old male liver transplant recipient presented with fever, chills, and abdominal pain.
Imaging revealed persistent confluent microabscesses in the right liver lobe despite antibiotic treatment.
The patient underwent a hepatectomy for the abscess.

Findings:

Histological examination confirmed malakoplakia as the cause of the inflammatory process.
This is the first reported case of malakoplakia in an adult transplanted liver.
The findings suggest malakoplakia can occur in compromised hepatic allografts.

Implications:

This case expands the known clinical spectrum of malakoplakia.
It underscores the importance of considering rare diagnoses in transplant patients with persistent infections.
Further research may elucidate the pathogenesis of malakoplakia in transplanted organs.