Related Experiment Video

Updated: Jun 13, 2025

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
10:07

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Published on: October 27, 2023

1.6K

Positron emission tomography probes for stem cell monitoring: a review

Ligong Xu1, Jingjing Shi2, Shuang Wu3

  • 1Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.

American Journal of Translational Research
|September 12, 2024
PubMed

Insights

Positron emission tomography (PET) imaging offers a noninvasive method to track stem cells after transplantation. This approach enhances understanding of stem cell behavior, paving the way for wider clinical applications in regenerative medicine.

Area of Science:

  • Regenerative Medicine
  • Biomedical Imaging
  • Cell Biology

Background:

  • Stem cells hold significant therapeutic potential for tissue regeneration and treating various diseases.
  • Clinical adoption of stem cell therapies is limited by incomplete understanding of cell behavior, efficacy, and safety.
  • Positron emission tomography (PET) imaging presents a promising noninvasive tool to address these knowledge gaps.

Purpose of the Study:

  • To review the application of PET imaging for monitoring stem cell dynamics post-transplantation.
  • To highlight the role of molecular probes in enabling quantitative and longitudinal evaluation of transplanted stem cells.
  • To discuss how PET imaging can advance the clinical understanding and application of stem cell therapies.

Main Methods:

  • Systematic review of existing literature on PET imaging probes for stem cell tracking.
  • Delineation of various molecular probes designed for *in vivo* monitoring of the stem cell life cycle.
  • Focus on the noninvasive, quantitative, and longitudinal assessment capabilities of PET imaging.

Main Results:

  • PET imaging allows for real-time, noninvasive monitoring of stem cell behavior after transplantation.
  • Specific molecular probes facilitate the evaluation of stem cell fate, migration, and viability *in vivo*.
  • Longitudinal data from PET imaging can provide crucial insights into the efficacy and safety of stem cell therapies.

Conclusions:

  • PET imaging is a powerful tool for bridging the knowledge gap in stem cell biology and therapy.
  • The use of PET imaging probes can significantly improve the understanding of stem cell behavior post-transplantation.
  • Implementing PET imaging can revolutionize clinical stem cell applications, enhancing therapeutic outcomes.
Keywords:
Stem cellsin vivo trackingmolecular probespositron emission tomography imaging

More Related Videos

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice10:25

Multimodal Imaging of Stem Cell Implantation in the Central Nervous System of Mice

Published on: June 13, 2012

11.1K
Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging09:06

Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging

Published on: March 31, 2008

9.8K

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.1K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
91