Clinical significance of preoperative albumin and alkaline phosphatase in colorectal cancer: a systematic review and meta-analysis
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Summary
This summary is machine-generated.Low preoperative albumin and high alkaline phosphatase levels in colorectal cancer patients indicate a higher risk of complications and reduced survival. These biomarkers can help predict patient outcomes.
Area Of Science
- Oncology
- Biochemistry
- Medical Diagnostics
Background
- Colorectal cancer (CRC) management involves assessing patient prognosis.
- Preoperative serum markers may offer predictive value for postoperative outcomes.
Purpose Of The Study
- To examine the association between preoperative serum albumin (ALB) and alkaline phosphatase (ALP) levels and postoperative outcomes in CRC patients.
Main Methods
- A systematic literature review and meta-analysis of 20 studies with 61,296 participants.
- Data synthesized using a random effects model.
- Study quality assessed with Newcastle-Ottawa Scale and Cochrane Risk of Bias Tool.
Main Results
- Hypoalbuminemia (ALB < 3.5 g/dl) correlated with increased risk of postoperative complications (OR=2.56), mortality (OR=4.54), and poorer survival (HR=2.09).
- Elevated ALP levels were linked to higher risk of poor overall survival (HR=1.67).
- Publication bias was observed in some included studies.
Conclusions
- Preoperative hypoalbuminemia and elevated ALP are significant indicators of adverse postoperative events and reduced survival in CRC.
- These biomarkers show potential for prognostic assessment in colorectal cancer patients.
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