Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone turnover in male puberty: a longitudinal study.

B J Riis, S Krabbe, C Christiansen

    Calcified Tissue International
    |May 1, 1985
    PubMed
    Summary

    Male puberty involves a significant increase in testosterone (T), which stimulates bone formation markers like bone Gla protein (BGP) and alkaline phosphatase (AP), leading to increased bone mineral content (BMC).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial.

    Bone·2018
    Same author

    Cohort Profile: The Prospective Epidemiological Risk Factor (PERF) study.

    International journal of epidemiology·2016
    Same author

    Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials.

    Osteoarthritis and cartilage·2015
    Same author

    OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.

    Osteoarthritis and cartilage·2015
    Same author

    Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis.

    Bone·2012
    Same author

    Efficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term extension study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011

    Area of Science:

    • Endocrinology
    • Pediatrics
    • Bone Biology

    Background:

    • Puberty is a critical period for skeletal development.
    • Hormonal changes during male puberty significantly influence bone metabolism.
    • Understanding the relationship between hormones and bone formation is crucial for adolescent health.

    Purpose of the Study:

    • To investigate the relationship between serum testosterone levels and bone formation markers during male puberty.
    • To determine the temporal association between hormonal changes and bone mineral accrual in adolescent males.
    • To elucidate the role of testosterone in stimulating bone formation and apposition.

    Main Methods:

    • Longitudinal study design with 18 male participants.
    • Bi-monthly measurements of serum bone Gla protein (BGP), testosterone (T), alkaline phosphatase (AP), and calcitonin over at least two years.
    • Assessment of bone mineral content (BMC) changes in relation to hormonal fluctuations.

    Main Results:

    • A significant increase in serum testosterone (T) was observed during puberty (P < 0.001).
    • Serum bone Gla protein (BGP) and alkaline phosphatase (AP) showed a near-simultaneous increase with testosterone (P < 0.001).
    • Bone mineral content (BMC) increase peaked approximately 10 months after the maximal testosterone surge, with no significant change in calcitonin.

    Conclusions:

    • The surge in testosterone during male puberty acutely stimulates bone formation, as indicated by BGP and AP levels.
    • This hormonal stimulation is followed by a significant increase in bone apposition, measured by BMC.
    • Testosterone plays a pivotal role in driving skeletal maturation during adolescence.

    Related Experiment Videos