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Related Experiment Videos

Persistent hemiballismus with lesions outside the subthalamic nucleus.

A E Lang

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |May 1, 1985
    PubMed
    Summary

    Hemiballismus, a movement disorder, can stem from striatal lesions, causing persistent involuntary movements. Lesions outside the subthalamic nucleus may allow for spontaneous resolution, with pimozide showing some benefit.

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    Area of Science:

    • Neurology
    • Neuroscience
    • Movement Disorders

    Background:

    • Hemiballismus is characterized by involuntary, violent, and large-amplitude limb movements.
    • Causative lesions are often found in the subthalamic nucleus, but atypical presentations exist.

    Purpose of the Study:

    • To investigate the role of striatal lesions in hemiballismus.
    • To explore potential mechanisms for spontaneous resolution of hemiballistic movements.
    • To evaluate the efficacy of sodium valproate and pimozide in managing hemiballismus.

    Main Methods:

    • Case report of two patients with striatal lesions documented by CT scan.
    • Clinical observation of movement disorder persistence and resolution.
    • Pharmacological trial of sodium valproate and pimozide.

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    Main Results:

    • Two patients with striatal lesions experienced persistent hemiballismus for 1 and 5 years.
    • A third patient with self-limited hemiballismus showed no causative lesion on CT scan.
    • Sodium valproate was ineffective in all patients.
    • Pimozide reduced the severity of hemiballismus in patients with longstanding symptoms.

    Conclusions:

    • Striatal lesions can cause persistent hemiballismus.
    • Lesions outside the subthalamic nucleus may disrupt compensatory mechanisms, potentially leading to spontaneous resolution.
    • Pimozide may offer symptomatic relief for chronic hemiballismus.