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ICP - could there be a virus in the works?

Sarah K Giles1, Wm Bill Hague2, Robert A Edwards1

  • 1Flinders Accelerator for Microbiome Exploration, Flinders University, Bedford Park, SA, Australia.

Obstetric Medicine
|September 12, 2024
PubMed

Intrahepatic cholestasis of pregnancy (ICP) is the most common liver-specific disorder affecting pregnant women, with an Australian incidence of 0.6% pa and recurring in 70% of those affected. ICP causes mild to severe pruritus, often resulting in considerable skin excoriations, profound sleep disturbances, and severe anxiety, and yet the aetiology and optimal treatment or management of this condition remains unknown. In this review, we consider the role of viruses in causing or exacerbating ICP and discuss viruses that have been most closely implicated in the disease, including the role of Hepatitis B and Hepatitis C viruses in ICP.

Keywords:
ICPIntrahepatic cholestasis of pregnancyhepatitisvirus

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