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Published on: November 7, 2020
Epidemiological trends in respiratory pathogens infections among children post-COVID-19: A cross-sectional study
Tiewei Li1, Xiaojuan Li1, Xinrui Liu1
1Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Insights
Post-COVID-19, respiratory pathogen infections like influenza A virus and Mycoplasma pneumonia surged in children. Outbreaks occurred earlier than usual, highlighting the need for continued surveillance and clinical attention.
Area of Science:
- Pediatric infectious diseases
- Epidemiology
- Public health
Background:
- The COVID-19 pandemic significantly impacted global health, potentially altering the epidemiology of other infectious diseases.
- Understanding post-pandemic trends in pediatric respiratory infections is crucial for public health strategies.
Purpose of the Study:
- To investigate the epidemiological trends of common respiratory pathogens in children following the COVID-19 pandemic.
- To identify shifts in the timing and prevalence of infections caused by influenza A virus, influenza B virus, respiratory syncytial virus, adenovirus, and Mycoplasma pneumonia.
Main Methods:
- Retrospective analysis of electronic medical records for 575,373 children presenting with respiratory symptoms.
- Collection of demographic data and laboratory results for influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumonia (MP) testing.
- Statistical analysis using SPSS and GraphPad Prism software.
Main Results:
- Significant positive rates were observed for IAV (28.5%), MP (15.5%), ADV (11.9%), RSV (7.1%), and IBV (1.1%).
- Peak infection periods for IAV, RSV, ADV, and MP occurred earlier than in previous years, with notable surges in specific months.
- Children over 3 years old were predominantly affected by IAV, IBV, ADV, and MP, while RSV primarily impacted those under 6 years.
Conclusions:
- Respiratory pathogen infections exhibited distinct epidemic trends in children post-COVID-19.
- These findings underscore the importance of timely monitoring of pediatric respiratory pathogen epidemiology to inform public health and clinical practice.
Objective:
The aim of this study was to investigate the epidemiological trend of respiratory pathogens infections among children after the Coronavirus Disease 2019 (COVID-19) pandemic.
Methods:
This study enrolled 575,373 children who came to our hospital for relevant respiratory pathogen antigen/antibody testing due to respiratory symptoms such as fever and cough. The demographic and laboratory data, including age, gender, testing time, and influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumonia (MP) results, were collected from electronic medical records. SPSS (version 21.0) and GraphPad Prism 9 software were used for statistical analysis and figure creation.
Results:
79,746 children tested positive for IAV IgM, and 3196 children tested positive for IBV IgM, with an overall positive rate of 28.5 % for IAV and 1.1 % for IBV. IAV infections peaked at 21,502 cases in March 2023. 80,699 children underwent RSV IgM testing from April to October 2023, with 5726 (7.1 %) testing positive. The apex of RSV infections occurred in May 2023, with 2140 cases. Regarding ADV, 100,460 children underwent testing from April to October 2023, with 1981 (11.9 %) testing positive. The pinnacle of ADV infections reached 4546 cases in November 2023. Concerning MP, 474,913 children underwent MP testing, with 73,833 (15.5 %) testing positive. The zenith of MP infections occurred in November 2023, with 25,291 cases. Further analysis revealed that the outbreaks of these pathogens are occurring earlier than in previous years. Additionally, our data showed that children aged >3 years accounted for 79.6 %, 87.8 %, 88.6 %, and 77.8 % of the total IAV-positive, IBV-positive, ADV-positive, and MP-positive children, respectively. Conversely, RSV primarily infected children <6 years.
Conclusion:
Various respiratory pathogens showed an epidemic trend in children among children post-COVID-19. These results indicated that we should pay timely attention to the epidemiological trends and characteristics of respiratory pathogens in children after the COVID-19 pandemic and provide relevant information for society and clinical practice.
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