Epidemiological trends in respiratory pathogens infections among children post-COVID-19: A cross-sectional study

Tiewei Li1, Xiaojuan Li1, Xinrui Liu1

  • 1Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.

Heliyon
|September 12, 2024
PubMed

Insights

Post-COVID-19, respiratory pathogen infections like influenza A virus and Mycoplasma pneumonia surged in children. Outbreaks occurred earlier than usual, highlighting the need for continued surveillance and clinical attention.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology
  • Public health

Background:

  • The COVID-19 pandemic significantly impacted global health, potentially altering the epidemiology of other infectious diseases.
  • Understanding post-pandemic trends in pediatric respiratory infections is crucial for public health strategies.

Purpose of the Study:

  • To investigate the epidemiological trends of common respiratory pathogens in children following the COVID-19 pandemic.
  • To identify shifts in the timing and prevalence of infections caused by influenza A virus, influenza B virus, respiratory syncytial virus, adenovirus, and Mycoplasma pneumonia.

Main Methods:

  • Retrospective analysis of electronic medical records for 575,373 children presenting with respiratory symptoms.
  • Collection of demographic data and laboratory results for influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumonia (MP) testing.
  • Statistical analysis using SPSS and GraphPad Prism software.

Main Results:

  • Significant positive rates were observed for IAV (28.5%), MP (15.5%), ADV (11.9%), RSV (7.1%), and IBV (1.1%).
  • Peak infection periods for IAV, RSV, ADV, and MP occurred earlier than in previous years, with notable surges in specific months.
  • Children over 3 years old were predominantly affected by IAV, IBV, ADV, and MP, while RSV primarily impacted those under 6 years.

Conclusions:

  • Respiratory pathogen infections exhibited distinct epidemic trends in children post-COVID-19.
  • These findings underscore the importance of timely monitoring of pediatric respiratory pathogen epidemiology to inform public health and clinical practice.
Abstract

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