Urinary proteins in a patient with Tangier disease
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Abstract:
We have investigated the possibility that the mild proteinuria in a patient with Tangier disease is directly related to the plasma HDL-deficiency through excretion of apolipoprotein A-I (Mr 28,300). An increased urinary excretion of a 29,000 polypeptide was observed in this patient. However, western blot analysis of the urine showed that this protein was not apolipoprotein A-1 or its precursor form. Subsequent investigations identified the urinary protein as immunoglobulin light chains. The elevated excretion may be a consequence of the patient's plasma polyclonal gammopathy which had resulted from a chronic infection.
Insights
Mild proteinuria in Tangier disease is not due to apolipoprotein A-I excretion. Instead, increased urinary immunoglobulin light chains, linked to polyclonal gammopathy from chronic infection, were identified.
Area of Science:
- Nephrology
- Clinical Biochemistry
- Immunology
Background:
- Tangier disease is characterized by severe high-density lipoprotein (HDL) deficiency.
- Mild proteinuria is a potential, though not well-understood, clinical manifestation.
- The study investigates a potential link between HDL deficiency and proteinuria via apolipoprotein A-I (ApoA-I) excretion.