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Related Concept Videos

Translation01:31

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Jun 13, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Ultra-Early Diffuse Lung Disease in an Infant with Pathogenic Variant in Telomerase Reverse Transcriptase (TERT)

J Visekruna1, M Basa1, T Grba1

  • 1Department of Pulmonology, Mother and Child Health Institute of Serbia, Belgrade, Serbia.

Balkan Journal of Medical Genetics : BJMG
|September 12, 2024
PubMed
Summary
This summary is machine-generated.

Pathogenic variants in the telomerase reverse transcriptase (TERT) gene are linked to rare, early-onset diffuse lung disease in infants, even after severe viral pneumonia. This case highlights the critical role of genetic factors in childhood respiratory failure.

Area of Science:

  • Pediatric Pulmonology
  • Medical Genetics
  • Molecular Biology

Background:

  • Pathogenic variants in the telomerase reverse transcriptase (TERT) gene are associated with adult idiopathic pulmonary fibrosis.
Keywords:
cytomegalovirus (CMV)diffuse lung diseaseearly-onset respiratory failurethe TERT gene variants

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  • The role of TERT gene variants in childhood diffuse lung disease remains largely undescribed.