Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

6.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral nanoparticles drive enantiomer-specific osteogenic differentiation of stem cells and accelerate bone regeneration.

Science advances·2026
Same author

A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger.

Science advances·2026
Same author

Understanding of endo/lysosomal escape of nanomaterials in biomedical application.

Smart molecules : open access·2026
Same author

Small Gold Nanoparticles Alleviate Huntington's Disease via Modulating p38α Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1.

ACS nano·2025
Same author

33 Unresolved Questions in Nanoscience and Nanotechnology.

ACS nano·2025
Same author

Plaque-Targeted Delivery of Fluoride-Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy.

Advanced materials (Deerfield Beach, Fla.)·2025

Related Experiment Video

Updated: Jun 13, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.5K

In Vivo Interactions of Nucleic Acid Nanostructures With Cells.

Yu Xiao1, Zhihui Liang1, Moldir Shyngys1

  • 1Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Advanced Materials (Deerfield Beach, Fla.)
|September 12, 2024
PubMed
Summary

Nucleic acid nanostructures show promise as intracellular drug carriers. Understanding their in vivo cell interactions is key to advancing nanomedicine translation for better therapeutic outcomes.

Keywords:
bio‐nano interactiongene deliverynanomedicinesnucleic acid nanotechnologypreclinical research

More Related Videos

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.1K
In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions
08:14

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

Published on: July 17, 2019

12.6K

Related Experiment Videos

Last Updated: Jun 13, 2025

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.5K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.1K
In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions
08:14

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

Published on: July 17, 2019

12.6K

Area of Science:

  • Nanomedicine
  • Molecular Biology
  • Biotechnology

Background:

  • Nucleic acid nanostructures are promising intracellular carriers for therapeutic cargoes.
  • Clinical translation of these nanomedicines is limited due to a lack of mechanistic understanding of in vivo cellular interactions.

Purpose of the Study:

  • To review recent advancements in understanding the in vivo cellular interactions of key nucleic acid nanostructures.
  • To highlight progress in preclinical models (rodents, large animals) and human studies.
  • To provide future research directions and discuss regulatory aspects.

Main Methods:

  • Review of literature published in the last five years focusing on in vivo cellular interactions of nucleic acid nanostructures.
  • Analysis of studies examining cellular distribution and responses in various tissues.
  • Inclusion of data from rodent, large animal, and human studies.

Main Results:

  • Detailed examination of four major types: tile-based, origami, spherical nucleic acid, and nucleic acid nanogels.
  • Emphasis on cellular uptake, biodistribution, and biological responses in vivo.
  • Progress in understanding interactions across different animal models, including humans.

Conclusions:

  • A deeper mechanistic insight into in vivo cellular interactions is crucial for advancing nucleic acid nanomedicines.
  • Future research should integrate materials science and biology perspectives.
  • Regulatory considerations are important for clinical translation.