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Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review

Duy Cao Phuong Le1,2, Hoa The Bui1, Yen Thi Hai Vu3

  • 1Departmentof Cardiovascular Intervention, Nguyen Tri Phuong Hospital, Ho Chi Minh city, 700000, Vietnam.

Regenerative Medicine
|September 12, 2024
PubMed

Insights

Induced pluripotent stem cells (iPSCs) show promise for treating heart failure (HF). iPSC therapy significantly improved heart function and reduced cardiac remodeling in animal models, with no increased risk of arrhythmias.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Therapy

Background:

  • Heart failure (HF) is a leading cause of mortality, with over 266,400 deaths annually.
  • Current HF treatments have limitations, and mortality rates remain high.
  • Induced pluripotent stem cells (iPSCs) present a novel therapeutic avenue for HF.

Purpose of the Study:

  • To review and assess the efficacy of iPSC-based treatments for heart failure.
  • To evaluate the impact of iPSC therapy on cardiac function and remodeling in preclinical models.

Main Methods:

  • A systematic review of studies was conducted using major scientific databases: PubMed, ScienceDirect, and Web of Science.
  • Included studies focused on iPSC-based interventions in animal models of heart failure.
  • Data from 25 studies involving 553 animals were analyzed.

Main Results:

  • iPSC treatment significantly improved ejection fraction (EF) by 8.6 points (p < 0.001).
  • Fractional shortening also showed significant improvement (MD = 6.38, p < 0.001).
  • Therapy reduced ventricular remodeling without elevating arrhythmia risk.

Conclusions:

  • iPSC-based therapy demonstrates efficacy in improving cardiac function in HF animal models.
  • The treatment effectively reduces ventricular volumes and remodeling.
  • These findings align with positive outcomes observed in early clinical trials, supporting further investigation.

Keywords:
heart failureinduced pluripotent stem cellsmeta-analysisoutcomestreatment

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