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Modern Perspective of Lactate Metabolism.
J Vavřička1, P Brož, D Follprecht
1Department of Sports Medicine and Active Health Sciences, Faculty of Medicine in Pilsen, Charles University, Czech Republic, Jakub.vavricka@lfp.cuni.cz.
Physiological Research
|September 12, 2024
Summary
Lactate, once a metabolic waste, is now recognized as a vital signaling molecule. This review clarifies lactate
Area of Science:
- Biochemistry and Metabolism
- Cellular Signaling
Background:
- Lactate, traditionally viewed as a glycolytic byproduct and metabolic waste, is now understood as a crucial signaling molecule.
- Historical misconceptions linked elevated lactate solely to hypoxia, but current research reveals broader physiological roles.
- Despite its importance, public and professional understanding of lactate's value in human physiology and clinical applications remains limited.
Purpose of the Study:
- To consolidate and update current knowledge on lactate metabolism and its diverse biological functions.
- To disseminate comprehensive information about lactate's significance to the professional scientific community.
- To address and correct persistent misconceptions regarding lactate's role in health and disease.
Main Methods:
- Comprehensive literature review of recent research on lactate metabolism and signaling.
- Analysis of studies investigating lactate's role in various physiological and pathological conditions.
- Synthesis of information to provide a refreshed perspective on lactate's multifaceted functions.
Main Results:
- Lactate is continuously produced under aerobic conditions and acts as an important signaling molecule.
- Lactate plays multifaceted roles in various biological processes beyond anaerobic glycolysis.
- Current evidence challenges the long-held belief that lactate accumulation is exclusively tied to hypoxia.
Conclusions:
- Lactate possesses significant physiological importance, acting as a key signaling molecule.
- A deeper understanding of lactate metabolism and its 'lactate shuttle' functions is critical for advancing clinical and performance science.
- This review aims to enhance professional awareness and understanding of lactate's true value.
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