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Implementation and Evaluation Strategies for Pharmacogenetic Testing in Hospital Settings: A Scoping Review
Angela Wu1,2, Edward J Raack2,3, Colin J D Ross2,4
1Department of Experimental Medicine, University of British Columbia.
Therapeutic Drug Monitoring
|September 12, 2024
Summary
Pharmacogenetic testing improves drug safety and efficacy. This review identifies implementation and evaluation strategies for clinical pharmacogenetic programs, highlighting physician engagement as key for integrating results into practice.
Area of Science:
- Clinical Pharmacology
- Genetics
- Healthcare Management
Background:
- Pharmacogenetic testing enhances drug safety and efficacy in clinical practice.
- Numerous studies explore pharmacogenetic implementation, identifying barriers and facilitators.
- A gap exists between identifying barriers/facilitators and developing clinical strategies for pharmacogenetic testing.
Purpose of the Study:
- To review implementation and evaluation strategies of pharmacogenetic testing programs.
- To bridge the gap between identified barriers and facilitators and clinical response strategies.
- To understand how pharmacogenetic testing is integrated into hospital settings.
Main Methods:
- A PRISMA-compliant scoping review was performed.
- Studies focused on pharmacogenetic testing programs in hospital settings.
- Included quantitative, qualitative, and mixed-methods research.
Main Results:
- 232 studies of clinical pharmacogenetic programs were included.
- Psychiatry (26%) and oncology (16%) were leading specialties, with 19% institutional programs.
- Physician engagement is crucial for incorporating pharmacogenetic results into clinical decisions, despite varied delivery methods.
Conclusions:
- Further research is needed on the sustainability of pharmacogenetic testing initiatives.
- Findings offer insights into implementation and evaluation strategies across specialties.
- Strategies can inform improvements in clinical pharmacogenetic testing adoption and effectiveness.
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