Related Experiment Video
Updated: Jun 13, 2025
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
Published on: May 18, 2022
Defining familial longevity and developing a familial longevity score for unbiased epigenetic studies in a birth
Jasmin C Pflaum1, Vincent D Gaertner1, Susanne Brandstetter2,3
1Department of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), of the University of Regensburg & the Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.
Abstract:
Aim: Longevity accumulating in families has genetic and epigenetic components. To study early and unbiased epigenetic predictors of longevity prospectively, a birth cohort would be ideal. However, the original family longevity selection score (FLoSS) focuses on populations of elderly only.Methods: In the German birth cohort KUNO-Kids we assessed when information for such scores may be best collected and how to calculate an adapted FLoSS.Results: A total of 551 families contributed to adapted FLoSS, with a mean score of -0.15 (SD 2.33). Adapted FLoSS ≥7 as a marker of exceptional longevity occurred in 3.3% of families, comparable to original FLoSS in elderly.Conclusion: An adapted FLoSS from data collectable postnatally may be a feasible tool to study unbiased epigenetic predictors for longevity.
Related Concept Videos
01:29Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
02:30Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...