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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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Developmental dyslexia in children with perinatal exposure to hypoxia: A systematic review

Bartosz M Radtke1, Małgorzata Lipowska2, Łucja Bieleninik2,3,4

  • 1Laboratory of Psychological and Educational Tests, Gdańsk, Poland.

Plos One
|September 12, 2024
PubMed

Insights

This study found no eligible research linking prenatal or delivery hypoxia to developmental dyslexia in school-aged children. The association between hypoxia and dyslexia remains undetermined due to a lack of studies.

Area of Science:

  • Perinatal medicine
  • Developmental neuroscience
  • Pediatric neurology

Background:

  • Inconclusive evidence exists regarding health events during labor and adverse school-age outcomes.
  • No prior systematic reviews have examined the link between perinatal hypoxia and developmental dyslexia.
  • Investigating the association between hypoxia and developmental dyslexia is crucial for understanding neurodevelopmental disorders.

Purpose of the Study:

  • To systematically review and assess the association between hypoxia during pregnancy or delivery and the occurrence of developmental dyslexia in school-aged children.
  • To identify and synthesize existing observational studies investigating the hypoxia-dyslexia link.
  • To determine if perinatal hypoxia is a risk factor for developmental dyslexia.

Main Methods:

  • A comprehensive search of multiple electronic databases (PubMed, PsycINFO, Web of Science, EMBASE, Cochrane Library) and handsearching was performed.
  • Included studies were observational (cohort, case-control) with hypoxia as exposure and developmental dyslexia as outcome.
  • Eligibility criteria were not limited by language or publication year, with two independent reviewers assessing studies.

Main Results:

  • The literature search was conducted up to April 1, 2023, yielding 1,336 abstracts.
  • Six studies were initially assessed for eligibility after abstract screening.
  • Critically, none of the identified studies met the pre-specified eligibility criteria for inclusion.

Conclusions:

  • No eligible studies were found, preventing an assessment of the association between hypoxia and developmental dyslexia.
  • The relationship between hypoxia during pregnancy or delivery and dyslexia in school-aged children remains unknown.
  • Further research is needed to explore this potential association.
Abstract

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